The past 20 years have brought an exponential increase in our knowledge about the pathophysiology of metabolic disease states, including obesity. We now understand why lifestyle alone is not sufficient for many people to manage these disease states. With knowledge comes new treatment options, including new medications that are bringing life saving help and quality of life improvement to thousands of people living with obesity. In this session we provide an overview of currently approved anti-obesity medications (AOMs), the medications in the pipeline, mechanisms of action and dietary and lifestyle implications to complement AOMs and mitigate common side effects.