The global nutraceutical market (functional foods and dietary supplements) is expected to reach $578.23 billion by 2025, and a search for "cholesterol-lowering supplements" on an online shopping site yields over 600 results. Patients are seeking out natural methods of treating hypercholesterolemia, and dietitians must be equipped to support them with evidence-based recommendations. Nutraceuticals have multiple mechanisms to lower LDL-cholesterol when combined with diet and/or medications (statins). They have other positive effects, e.g., reduce artery stiffness, improve artery health & reduce inflammation. They appear to be well-tolerated, safe, and effective for statin-intolerant patients. While not intended to replace pharmacological therapy, nutraceuticals can help achieve treatment targets, particularly in 1) patients with mild to moderate lipid elevations, 2) statin-intolerant patients, and 3) patients on pharmacological treatment but not quite at goal. This session will review the current body of evidence for lowering LDL-cholesterol with nutraceuticals and provide evidence-based recommendations to help patients reduce LDL-cholesterol. We will also identify the role of vitamins and minerals in the prevention of CVD.